Hormone Replacement Therapy News
"Studies Support Isoflavones for Hot Flushes"
January 17, 2007
A recent analysis of data from 17 separate studies on the efficacy of isoflavones to treat hot flushes and other menopause symptoms found that they can be somewhat effective, and may provide an alternative to dangerous hormone replacement therapy drugs.
“This meta-analysis of the effects of isoflavone[s] … on the frequency of menopausal flushing found a statistically significant, although clinically modest effect, and that the extent of benefit appeared to be positively associated with the frequency of the flushes and possibly the dose of isoflavone used,” said the study authors.
The meta-analysis, led by Laurence Howes of the Griffith University School of Medicine, looked at data from 17 separate, randomized, and controlled studies that lasted at least four weeks. They were taken from the Pre-Medline, Medline, Cochrane, and PubMed databases. The analysis appears in the journal Maturitas.
“The results of the study tend to support the recommendation of the North American menopause society that … for women with frequent hot flashes, clinicians may consider recommending soy foods or soy isoflavone supplements,” the authors said.
What are Isoflavones?
Isoflavones are substances derived from plants that interact with the body in a way similar to estrogen, but not as strongly.
Isoflavones have been the subject of much study for their suspected ability to slow aging and prevent cancer in menopausal women without having to resort to medications that could cause serious medical conditions.
The meta-analysis seems to bear these suspicions out, though the authors noted that there were significant differences in the measured efficacy of isoflavones between studies.
“The percentage reduction in flushes was significantly related to the number of baseline flushes per day and the dose of isoflavone studied,” the researchers wrote.
Study Limitations
This meta-analysis does have limitations worth considering. For one, only the number (not the severity) of hot flushes was measured. The study also neglected to measure the effect of isoflavones on menopause symptoms besides hot flushes.
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If you are currently taking hormone replacement therapy,
the combination of estrogen and progestin, you are advised
to contact your doctor IMMEDIATELY
for hormone replacement therapy alternatives.
For more information on hormone replacement therapy alternatives
and your legal rights, please
contact a hormone replacement therapy lawyer.
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